Gene information
Official symbol DPP4
Official full name dipeptidyl peptidase 4
Gene type protein-coding gene
Chromosome2q24.2
Alias symbolDPPIV
Previous symbolCD26; ADCP2
Gene familyCD molecules; DASH family
Resources
Entrez Gene 1803
HGNC HGNC:3009
Ensembl ENSG00000197635
Vega OTTHUMG00000132056
UCSC uc002ubz.4
GO terms: 103 records
GO Description Category LogP Number of genes Detail
GO:0000323 lytic vacuole GO Cellular Components -7.25784656 30 More
GO:0001618 virus receptor activity GO Molecular Functions -7.88412825 17 More
GO:0001666 response to hypoxia GO Biological Processes -40.6131384 77 More
GO:0001667 ameboidal-type cell migration GO Biological Processes -17.0771232 40 More
GO:0001775 cell activation GO Biological Processes -43.3738118 71 More
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0002683 negative regulation of immune system process GO Biological Processes -26.6415063 77 More
GO:0002685 regulation of leukocyte migration GO Biological Processes -36.943236 43 More
GO:0002686 negative regulation of leukocyte migration GO Biological Processes -7.70467721 14 More
GO:0002688 regulation of leukocyte chemotaxis GO Biological Processes -31.6279962 32 More
GO:0002689 negative regulation of leukocyte chemotaxis GO Biological Processes -4.98522137 5 More
GO:0002694 regulation of leukocyte activation GO Biological Processes -32.0887020 60 More
GO:0002696 positive regulation of leukocyte activation GO Biological Processes -27.9249645 47 More
GO:0004175 endopeptidase activity GO Molecular Functions -25.2809598 44 More
GO:0004252 serine-type endopeptidase activity GO Molecular Functions -24.0834770 30 More
GO:0005764 lysosome GO Cellular Components -7.25784656 30 More
GO:0005774 vacuolar membrane GO Cellular Components -1.32038132 10 More
GO:0005911 cell-cell junction GO Cellular Components -3.41801827 38 More
GO:0005925 focal adhesion GO Cellular Components -8.40302345 46 More
GO:0006518 peptide metabolic process GO Biological Processes -2.74792434 15 More
GO:0006897 endocytosis GO Biological Processes -8.07395492 24 More
GO:0006898 receptor-mediated endocytosis GO Biological Processes -6.77623895 13 More
GO:0006935 chemotaxis GO Biological Processes -33.1726887 55 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007626 locomotory behavior GO Biological Processes -5.45844211 23 More
GO:0008233 peptidase activity GO Molecular Functions -21.0463733 46 More
GO:0008236 serine-type peptidase activity GO Molecular Functions -23.9716175 31 More
GO:0008238 exopeptidase activity GO Molecular Functions -3.53660715 7 More
GO:0010631 epithelial cell migration GO Biological Processes -10.0481870 21 More
GO:0010715 regulation of extracellular matrix disassembly GO Biological Processes -5.83914312 5 More
GO:0010716 negative regulation of extracellular matrix disassembly GO Biological Processes -6.84560710 4 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0016032 viral process GO Biological Processes -8.84449931 34 More
GO:0016324 apical plasma membrane GO Cellular Components -4.50542891 15 More
GO:0016485 protein processing GO Biological Processes -23.0561441 30 More
GO:0016486 peptide hormone processing GO Biological Processes -7.86007212 8 More
GO:0017171 serine hydrolase activity GO Molecular Functions -24.8900503 32 More
GO:0019058 viral life cycle GO Biological Processes -10.6409496 31 More
GO:0019065 receptor-mediated endocytosis of virus by host cell GO Biological Processes -3.59511628 3 More
GO:0022407 regulation of cell-cell adhesion GO Biological Processes -32.4337382 53 More
GO:0022409 positive regulation of cell-cell adhesion GO Biological Processes -25.7751074 39 More
GO:0030027 lamellipodium GO Cellular Components -1.61995196 15 More
GO:0030055 cell-substrate junction GO Cellular Components -9.04790297 48 More
GO:0030139 endocytic vesicle GO Cellular Components -10.5530816 23 More
GO:0030155 regulation of cell adhesion GO Biological Processes -41.8400792 131 More
GO:0030545 signaling receptor regulator activity GO Molecular Functions -87.4728446 102 More
GO:0030546 signaling receptor activator activity GO Molecular Functions -90.4065983 101 More
GO:0031252 cell leading edge GO Cellular Components -1.97716247 28 More
GO:0031253 cell projection membrane GO Cellular Components -3.08510132 12 More
GO:0031294 lymphocyte costimulation GO Biological Processes -2.77870822 4 More
GO:0031295 T cell costimulation GO Biological Processes -2.15842877 6 More
GO:0032102 negative regulation of response to external stimulus GO Biological Processes -54.2675416 110 More
GO:0033555 multicellular organismal response to stress GO Biological Processes -7.79385832 16 More
GO:0033632 regulation of cell-cell adhesion mediated by integrin GO Biological Processes -5.05315969 4 More
GO:0035641 locomotory exploration behavior GO Biological Processes -3.04620727 3 More
GO:0036293 response to decreased oxygen levels GO Biological Processes -40.9544531 79 More
GO:0040013 negative regulation of locomotion GO Biological Processes -30.7871461 81 More
GO:0042110 T cell activation GO Biological Processes -7.78997285 18 More
GO:0042330 taxis GO Biological Processes -33.0828571 55 More
GO:0042445 hormone metabolic process GO Biological Processes -9.53279610 17 More
GO:0042596 fear response GO Biological Processes -3.60825621 7 More
GO:0042803 protein homodimerization activity GO Molecular Functions -14.2815375 77 More
GO:0043542 endothelial cell migration GO Biological Processes -10.6625063 19 More
GO:0043603 cellular amide metabolic process GO Biological Processes -1.84597279 17 More
GO:0044000 movement in host GO Biological Processes -9.40214314 25 More
GO:0044403 biological process involved in symbiotic interaction GO Biological Processes -18.5885778 29 More
GO:0044406 adhesion of symbiont to host GO Biological Processes -4.89406977 4 More
GO:0044409 entry into host GO Biological Processes -10.3666963 14 More
GO:0045121 membrane raft GO Cellular Components -30.0775030 71 More
GO:0045177 apical part of cell GO Cellular Components -8.17813885 46 More
GO:0045321 leukocyte activation GO Biological Processes -25.4958219 48 More
GO:0045499 chemorepellent activity GO Molecular Functions -2.36203981 3 More
GO:0045785 positive regulation of cell adhesion GO Biological Processes -29.6368249 50 More
GO:0046649 lymphocyte activation GO Biological Processes -10.1732143 26 More
GO:0046718 viral entry into host cell GO Biological Processes -10.4786216 14 More
GO:0046794 transport of virus GO Biological Processes -2.85684426 3 More
GO:0048018 receptor ligand activity GO Molecular Functions -91.0736151 101 More
GO:0050863 regulation of T cell activation GO Biological Processes -20.3209154 36 More
GO:0050865 regulation of cell activation GO Biological Processes -40.6877761 71 More
GO:0050867 positive regulation of cell activation GO Biological Processes -31.2431659 51 More
GO:0050870 positive regulation of T cell activation GO Biological Processes -17.6497748 28 More
GO:0050919 negative chemotaxis GO Biological Processes -2.66946679 4 More
GO:0050920 regulation of chemotaxis GO Biological Processes -36.3269885 43 More
GO:0050922 negative regulation of chemotaxis GO Biological Processes -8.57011989 17 More
GO:0051129 negative regulation of cellular component organization GO Biological Processes -13.1016989 75 More
GO:0051249 regulation of lymphocyte activation GO Biological Processes -22.6120519 46 More
GO:0051251 positive regulation of lymphocyte activation GO Biological Processes -20.2181987 37 More
GO:0051604 protein maturation GO Biological Processes -20.0856790 31 More
GO:0051701 biological process involved in interaction with host GO Biological Processes -10.6054189 28 More
GO:0070482 response to oxygen levels GO Biological Processes -40.7566635 82 More
GO:0071622 regulation of granulocyte chemotaxis GO Biological Processes -10.3031127 11 More
GO:0075509 endocytosis involved in viral entry into host cell GO Biological Processes -3.47400635 3 More
GO:0090022 regulation of neutrophil chemotaxis GO Biological Processes -5.21154381 9 More
GO:0090130 tissue migration GO Biological Processes -11.7623300 24 More
GO:0090132 epithelium migration GO Biological Processes -9.75855830 21 More
GO:0098857 membrane microdomain GO Cellular Components -30.8181788 72 More
GO:0140272 exogenous protein binding GO Molecular Functions -8.63789613 18 More
GO:0140448 signaling receptor ligand precursor processing GO Biological Processes -9.03552172 9 More
GO:1902622 regulation of neutrophil migration GO Biological Processes -4.86040077 10 More
GO:1903037 regulation of leukocyte cell-cell adhesion GO Biological Processes -23.2079690 66 More
GO:1903039 positive regulation of leukocyte cell-cell adhesion GO Biological Processes -20.7355312 32 More
GO:1903053 regulation of extracellular matrix organization GO Biological Processes -8.17680088 15 More
GO:1903054 negative regulation of extracellular matrix organization GO Biological Processes -8.11586193 6 More
KEGG pathways: 1 record
KEGG Description Category LogP Number of genes Detail
hsa04974 Protein digestion and absorption KEGG Pathway -4.19153592 8 More
Drug-Gene interaction
view
Related drugs: 24 records
Drug name Interaction type Source PMID View
alogliptin inhibitor TdgClinicalTrialTTD view
alogliptin benzoate inhibitor ChemblInteractions view
anagliptin TTD 19246581 view
begelomab antibodyinhibitor ChemblInteractionsTTD view
bisegliptin TdgClinicalTrialTTD view
captopril NCI 17531305 view
carmegliptin inhibitor ChemblInteractions view
denagliptin TTD view
dutogliptin TdgClinicalTrialTTD view
enalapril NCI 16678199 view
evogliptin TTD view
gemigliptin TTD view
gosogliptin inhibitor ChemblInteractionsTTD 2136666510592235 view
linagliptin inhibitor ChemblInteractionsTTD 22149370 view
omarigliptin inhibitor ChemblInteractionsTTD view
saxagliptin inhibitor TdgClinicalTrialTENDTTD 16033281 view
saxagliptin hydrochloride inhibitor ChemblInteractions view
sitagliptin inhibitor TdgClinicalTrialTENDTTD 173150491735251616490580174076491685507211752352190659931759323616868220166829371633828318182122 view
sitagliptin phosphate inhibitor ChemblInteractions view
teneligliptin inhibitor TTD view
trelagliptin TTD view
trelagliptin succinate inhibitor ChemblInteractions view
valacyclovir DTC 24185376 view
vildagliptin inhibitor TdgClinicalTrialChemblInteractionsTTD 81005231556220019149538 view
Related studies: 3 records
Molecular factor Omics type Application Objective MI type Reference
dipeptidyl peptidase 4 proteomics left ventricular dysfunction[prognosis (bad)] acute ST elevation myocardial infarction Post S et al. J Mol Cell Cardiol. 2012
dipeptidyl peptidase 4 proteomics left ventricular systolic dysfunction[prognosis (bad)] ST elevation myocardial infarction Li JW et al. Sci Rep. 2017
NM_001935.4:c.366+1153G>A genomics myocardial infarction[diagnosis] myocardial infarction Aghili N et al. Neuropeptides. 2012
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